Use of Myocardial Fractional Flow Reserve to Identify Predictors of Poor Prognosis after Percutaneous Coronary Interventions

ABSTRACTBackgroundSeveral studies were performed to define predictors of adverse events after percutaneous coronary intervention (PCI). Patients whose post-procedure myocardial fractional flow of reserve (FFR) is <0.90 have an incidence of major cardiac events at 6 months at least 3 times higher than those whose FFR is≥0.90. The aim of this study was to identify clinical, angiographic and procedure-related factors associated with a post-PCI FFR <0.90.MethodsOne hundred and ninety-three patients (256 lesions) treated between 2004 and 2005 were included, and FFR was measured before and after PCI in all of the treated vessels. Patients were divided into groups with FFR <0.90 and FFR≥0.90. Logistic regression multivariate analysis was used to determine the adjusted odds ratio (OR).ResultsFFR was measured in all lesions. No difference was observed in clinical parameters between groups. There were differences in angiographic and procedure-related parameters, however, when the logistic regression model was used, the only variable associated to post-PCI FFR <0.90 was the treatment of the left anterior descending artery (OR, 12.1; 95% CI, 6.4-22.9; P<0.01).ConclusionsThe only predictor of a FFR