Spindle activity phase-locked to sleep slow oscillations
- Klinzing, Jens G.
- Mölle, Matthias
- Weber, Frederik
- Supp, Gernot
- Hipp, Jörg F.
- Engel, Andreas K.
- Born, Jan
DOIAbstract
AbstractThe <1Hz slow oscillation (SO) and spindles are hallmarks of mammalian non-rapid eye movement and slow wave sleep. Spindle activity occurring phase-locked to the SO is considered a candidate mediator of memory consolidation during sleep. We used source localization of magnetoencephalographic (MEG) and electroencephalographic (EEG) recordings from 11 sleeping human subjects for an in-depth analysis of the temporal and spatial properties of sleep spindles co-occurring with SOs. Slow oscillations and spindles were identified in the EEG and related to the MEG signal, providing enhanced spatial resolution. In the temporal domain, we confirmed a phase-locking of classical 12–15Hz fast spindle activity to the depolarizing SO up-state and o...
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