Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway
The ability to control the differentiation of stem cells into specific neuronal types has a tremendo...
Many people worldwide suffer from motor neuron-related disorders such as amyotrophic lateral scleros...
Human induced pluripotent stem cell (hiPSC) derived motoneurons represent a crucial cellular tool to...
Our understanding of the intrinsic mechanosensitive properties of human pluripotent stem cells (hPSC...
Biophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is p...
Differentiation of stem cells into neurogenic lineage is of great interest for treatment of neurodeg...
Human induced pluripotent stem cells (hiPSCs) are differentiated into mature motor neurons by using ...
BackgroundTo maximize the translational utility of human induced pluripotent stem cells (iPSCs), the...
International audienceabd Human induced pluripotent stem cells (hiPSCs) are differentiated into matu...
Astrocytes, which can be obtained from neural stem cells (NSCs) by adding serum and/or recombinant p...
Until recently, adult mammals were not believed to maintain active neurogenesis into adulthood, and ...
BACKGROUND: There are no cures or efficacious treatments for severe motor neuron diseases. It is ext...
© 2020 The Royal Society of Chemistry. While the mechanotransduction-induced fate of adult neural st...
There are no cures or efficacious treatments for severe motor neuron diseases. It is extremely diffi...
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal an...
The ability to control the differentiation of stem cells into specific neuronal types has a tremendo...
Many people worldwide suffer from motor neuron-related disorders such as amyotrophic lateral scleros...
Human induced pluripotent stem cell (hiPSC) derived motoneurons represent a crucial cellular tool to...
Our understanding of the intrinsic mechanosensitive properties of human pluripotent stem cells (hPSC...
Biophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is p...
Differentiation of stem cells into neurogenic lineage is of great interest for treatment of neurodeg...
Human induced pluripotent stem cells (hiPSCs) are differentiated into mature motor neurons by using ...
BackgroundTo maximize the translational utility of human induced pluripotent stem cells (iPSCs), the...
International audienceabd Human induced pluripotent stem cells (hiPSCs) are differentiated into matu...
Astrocytes, which can be obtained from neural stem cells (NSCs) by adding serum and/or recombinant p...
Until recently, adult mammals were not believed to maintain active neurogenesis into adulthood, and ...
BACKGROUND: There are no cures or efficacious treatments for severe motor neuron diseases. It is ext...
© 2020 The Royal Society of Chemistry. While the mechanotransduction-induced fate of adult neural st...
There are no cures or efficacious treatments for severe motor neuron diseases. It is extremely diffi...
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal an...
The ability to control the differentiation of stem cells into specific neuronal types has a tremendo...
Many people worldwide suffer from motor neuron-related disorders such as amyotrophic lateral scleros...
Human induced pluripotent stem cell (hiPSC) derived motoneurons represent a crucial cellular tool to...
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