Renal tubular transport of gentamicin in the rat. The renal handling of gentamicin in the rat was examined by clearance, microinjection, and renal cortical-slice techniques. The steady-state renal clearance of 14C-gentamicin, when corrected for the 7.5% binding to plasma protein, was not significantly different from that of 3H-inulin. At the end of the renal clearance experiments, the cortical concentration of gentamicin was 93 ± 7 µg/g of tissue (N = 7), a concentration threefold greater than that of the medulla and 20-fold greater than that of serum. Absorption of 3H-gentamicin along the proximal convoluted tubule and loop of Henle was demonstrated by the tubular microinjection technique. No reabsorption of 3H-gentamicin was detected beyo...
A substantial amount of data is available to suggest that lysosomal sequestration of amino-glycoside...
Although gentamicin is known to accumulate and persist in the kidneys after systemic administration,...
Gentamicin is an antibiotic that exhibits a broad spectrum of activity and is particularly valuable ...
Micropuncture study of the handling of gentamicin by the rat kidney. Renal clearance and micropunctu...
Gentamicin remains one of the primary antibiotics used for treatment of gram-negative infections des...
Gentamicin remains one of the primary antibiotics used for treatment of gram-negative infections des...
Cortical and papillary absorptive defects in gentamicin nephrotoxicity. Renal function was examined ...
The injection in rats of 4 mg/kg gentamicin results in accumulation and continued presence of the an...
The injection in rats of 4 mg/kg gentamicin results in accumulation and continued presence of the an...
Gentamicin (GM) is a widely used antibiotic but shows renal toxicity. We produced a serum against GM...
Role of tubular obstruction in acute renal failure due to gentamicin. Gentamicin sulfate was adminis...
Urinary excretion and tissue accumulation of gentamicin and paraaminohippurate in postischemic rat k...
LAPKIN, ROBERT, RALPH BOWMAN AND GEORGE J. KALOYANIDE5: Effect of genta-micin on p-aminohippurate me...
Mechanisms of the defect in glomerular ultrafiltration associated with gentamicin administration. Mi...
Pharmacokinetics of gentamicin in the treatment of renal infection: A therapeutic anomaly explained....
A substantial amount of data is available to suggest that lysosomal sequestration of amino-glycoside...
Although gentamicin is known to accumulate and persist in the kidneys after systemic administration,...
Gentamicin is an antibiotic that exhibits a broad spectrum of activity and is particularly valuable ...
Micropuncture study of the handling of gentamicin by the rat kidney. Renal clearance and micropunctu...
Gentamicin remains one of the primary antibiotics used for treatment of gram-negative infections des...
Gentamicin remains one of the primary antibiotics used for treatment of gram-negative infections des...
Cortical and papillary absorptive defects in gentamicin nephrotoxicity. Renal function was examined ...
The injection in rats of 4 mg/kg gentamicin results in accumulation and continued presence of the an...
The injection in rats of 4 mg/kg gentamicin results in accumulation and continued presence of the an...
Gentamicin (GM) is a widely used antibiotic but shows renal toxicity. We produced a serum against GM...
Role of tubular obstruction in acute renal failure due to gentamicin. Gentamicin sulfate was adminis...
Urinary excretion and tissue accumulation of gentamicin and paraaminohippurate in postischemic rat k...
LAPKIN, ROBERT, RALPH BOWMAN AND GEORGE J. KALOYANIDE5: Effect of genta-micin on p-aminohippurate me...
Mechanisms of the defect in glomerular ultrafiltration associated with gentamicin administration. Mi...
Pharmacokinetics of gentamicin in the treatment of renal infection: A therapeutic anomaly explained....
A substantial amount of data is available to suggest that lysosomal sequestration of amino-glycoside...
Although gentamicin is known to accumulate and persist in the kidneys after systemic administration,...
Gentamicin is an antibiotic that exhibits a broad spectrum of activity and is particularly valuable ...