Evidence for a rapid action of levetiracetam compared to topiramate in refractory partial epilepsy
- Specchio, Luigi M.
- Boero, Giovanni
- Specchio, Nicola
- Agazio, Giusi De
- Palo, Alessia De
- Tommaso, Marina de
- Beghi, Ettore
- Neve, Angela La
DOIAbstract
SummaryThe objective of this observational study was to compare the efficacy of levetiracetam and topiramate during the first 15 days of add-on treatment in adults with refractory partial epilepsy.Two cohorts of patients with ≥3 simple or complex partial seizures with or without secondary generalisation per month over an 8-week baseline period received levetiracetam or topiramate in two distinct phases, in addition to standard antiepileptic treatment. During the first 15 days of the therapy, levetiracetam was added at the dosage of 250mg b.i.d. or topiramate at 25mg o.i.d. Efficacy parameters included number of seizure-free days (SFDs), mean and percent reduction in seizure frequency (in general and by type), and number of seizure-free pati...
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