0059: Infective endocarditis: clinical features and prognosis between 2004 and 2014 in a non-teaching hospital

Infective endocarditis (IE) despite diagnostic and therapeutic progress remains a severe disease. We describe clinical features and prognosis of patients with Duke-Li definite infective endocarditis between 2004 and 2014 in a non-teaching hospital and compare them with a similar study conducted 10 years earlier. Results are consistent with current French data, including in-hospital death rate of 16%. In accordance with the literature, we report on an increase in Staphylococcus IE, health care associated IE and endocarditis on pace maker leads, but without significant difference compared to our previous study. In univariate analysis, renal failure, age over 70 years and Staphylococcus aureus were associated with in-hospital mortality. In multivariate analysis, predictors of in-hospital death were renal failure and lack of surgery. There was a non-significant trend of excess mortality in Staphylococcus IE or in patient with heart failure. IE remains a severe disease and Staphylococcus aureus is more often involved. IE can be safely managed in a peripheral hospital provided that there is a partnership with a reference center