The response of NT-proBNP to intensified medication in advanced chronic heart failure
- Nakano, Hiroki
- Fuse, Koichi
- Takahashi, Minoru
- Yuasa, Sho
- Koshikawa, Tomoyasu
- Sato, Masahito
- Okabe, Masaaki
- Yamashina, Akira
- Aizawa, Yoshifusa
DOIAbstract
AbstractBackgroundThe clinical significance of excessively high serum NT-proBNP is poorly understood in chronic heart failure (HF).MethodsOne-hundred eighteen patients with advanced chronic HF (NYHA functional class III or IV) were admitted; of these patients, 42.4% exhibited NT-proBNP levels >10,000pg/ml. The patients were divided into three groups as follows: ≥400 and <10,000pg/ml, group I (n=68); ≥10,000 and <20,000pg/ml, group II (n=28); and ≥20,000pg/ml, group III (n=22). The determinants of elevated NT-proBNP levels and responsiveness to HF medications were compared among these groups. A subgroup of HF patients with normal serum creatinine was analyzed separately.ResultsOverall, cardiac, renal and laboratory parameters (serum creatini...
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