AbstractDownregulation of the TCR complex is believed to be intimately tied to T cell activation, allowing serial triggering of receptors and desensitization of stimulated cells. We studied transfected and transgenic T cells expressing CD3ζ chimeras to demonstrate that ligand engagement of the TCR or chimeras causes comodulation of nonengaged receptors. Comodulation required protein tyrosine kinase activity but not trans-phosphorylation of nonengaged receptors. The TCR appears to be downregulated by at least two mechanisms. One mechanism requires direct engagement, independent of signaling. The second requires signaling and downregulates nontriggered receptors. These results shed new light on the process of TCR downregulation and indicate t...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (e...
AbstractExpression of a TCRγ transgene in RAG-1−/− mice resulted in the development of a limited num...
International audienceDownregulation of the TCR complex is believed to be intimately tied to T cell ...
AbstractDownregulation of the TCR complex is believed to be intimately tied to T cell activation, al...
T cells are critical decision-makers in the immune system and their activation determines whether a ...
International audienceT cell receptors (TCRs) are protein complexes formed by six different polypept...
The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular ...
A T-cell-mediated immune response is initiated by the T-cell receptor (TCR) interacting with peptide...
The number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement su...
International audienceT cell activation by peptide/MHC complexes, superantigens, or mAbs induces the...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
T cell receptor (TCR)-mediated stimulation of T hybridomas leads to cell activation and lymphokine p...
In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. ...
An effective immune response in mammalian cells relies on a network of molecular interactions to det...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (e...
AbstractExpression of a TCRγ transgene in RAG-1−/− mice resulted in the development of a limited num...
International audienceDownregulation of the TCR complex is believed to be intimately tied to T cell ...
AbstractDownregulation of the TCR complex is believed to be intimately tied to T cell activation, al...
T cells are critical decision-makers in the immune system and their activation determines whether a ...
International audienceT cell receptors (TCRs) are protein complexes formed by six different polypept...
The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular ...
A T-cell-mediated immune response is initiated by the T-cell receptor (TCR) interacting with peptide...
The number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement su...
International audienceT cell activation by peptide/MHC complexes, superantigens, or mAbs induces the...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
T cell receptor (TCR)-mediated stimulation of T hybridomas leads to cell activation and lymphokine p...
In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. ...
An effective immune response in mammalian cells relies on a network of molecular interactions to det...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (e...
AbstractExpression of a TCRγ transgene in RAG-1−/− mice resulted in the development of a limited num...