Virulence genotype and nematode-killing properties of extra-intestinal Escherichia coli producing CTX-M β-lactamases
- Lavigne, J.-P.
- Blanc-Potard, A.-B.
- Bourg, G.
- Moreau, J.
- Chanal, C.
- Bouziges, N.
- O'Callaghan, D.
- Sotto, A.
DOIAbstract
ABSTRACTThis study evaluated the virulence potential of Escherichia coli isolates producing CTX-M β-lactamases. During a 24-month period, 33 extended-spectrum β-lactamase (ESBL)-producing E. coli, including 14 CTX-M-producers, were isolated from urinary tract infections at Nîmes University Hospital, France. The prevalence of 14 major virulence factors (VFs) was investigated by PCR and compared with the prevalence in a group of 99 susceptible E. coli isolates. Ten VFs were less prevalent (p <0.05) in the ESBL isolates than the susceptible E. coli, while iutA and traT were more prevalent in ESBL isolates (p <0.05). Moreover, the CTX-M-producing isolates had significantly fewer VFs than TEM-producing isolates. A novel infection model using the...
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