II. Evaluation of Phototoxicity of Salicylanilides and Similar Compounds by Photohemolysis

A system is described in which red blood cell photohemolysis is induced by salicylanilides and similar compounds. The range of chemical and physical conditions at which each compound reacts defines its ability as a photosensitizer. Results are correlated with the known clinical photoactivity of these compounds.Pre-irradiation by artificial and natural sunlight produced photoproducts which were evaluated by thin layer chromatography, ultraviolet spectroscopy, osmotic fragility, pH changes and toxicity to red blood cells