The gorlin formula validated against directly observed orifice area in porcine mitral bioprostheses

AbstractTo assess the effect of fluid flow on orifice area and to test the Gorlin formula, six Carpentier-Edwards mitral valve prostheses were studied in a positive displacement pulse duplicator at 20 different rate-stroke volume combinations. Peak transvalvular velocity (V max) was measured by continuous wave Doppler ultrasound, and orifice area was determined from hard copy of video images. Orifice area was directly related to mean flow (Q), although cusp opening behavior was asymmetric and complex and varied among the individual valves.There was a strong correlation between measured orifice area (OA) and the modified Gorlin relation, Q/V max (r = 0.88; p < 0.00001) given by the regression formula OA = 0.18 × Q/V max − 0.15. There was also a good correlation between measured orifice area and the conventional Gorlin relation, Q/root mean pressure drop. The derived empiric Gorlin constant did not vary significantly with flow