Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study
- Boyce, Steven W
- Bartels, Claus
- Bolli, Roberto
- Chaitman, Bernard
- Chen, John C
- Chi, Eric
- Jessel, Andreas
- Kereiakes, Dean
- Knight, John
- Thulin, Lars
- Theroux, Pierre
DOIAbstract
AbstractObjectivesTo evaluate the effects of cariporide on all-cause mortality or myocardial infarction at 36 days in patients at risk of myocardial necrosis after coronary artery bypass graft surgery.MethodsIn the coronary artery bypass graft cohort of the GUARD During Ischemia Against Necrosis trial, patients ≥18 years who required urgent coronary artery bypass graft, repeat coronary artery bypass graft, or had a history of unstable angina and ≥2 risk factors (age >65 years, female gender, diabetes mellitus, ejection fraction <35%, or left main or 3-vessel disease) were randomized to placebo (n = 743) or cariporide 20 mg (n = 736), 80 mg (n = 705), or 120 mg (n = 734). A 1-hour intravenous infusion was initiated shortly before surgery and...
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