Abstractα-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) that are characterized by α-synuclein (AS) aggregates in neurons or glia. PD and DLB feature neuronal AS-positive inclusions termed Lewy bodies (LB) whereas glial cytoplasmic inclusions (GCIs, Papp–Lantos bodies) are recognized as the defining hallmark of MSA. Furthermore, AS-positive cytoplasmic aggregates may also be seen in astroglial cells of PD/DLB and MSA brains. The glial AS-inclusions appear to trigger reduced trophic support resulting in neuronal loss. Moreover, microgliosis and astrogliosis can be found throughout the neurodegenerative br...
Background: Glia are traditionally known as support cells for neurons, and their role in neurodegene...
Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Pa...
Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates,...
Abstract α-Synuclein (AS)-positive inclusions are the pathological hallmark of Parkinson’s disease (...
Abstractα-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative disorders such...
Synucleinopathies encompass several neurodegenerative diseases, which include Parkinson's disease, d...
Multiple system atrophy, characterized by atypical Parkinsonism, results from central nervous system...
A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identific...
α-Synucleinopathies comprise a group of neurodegenerative disorders that share α-synuclein (αS) accu...
Selective loss of neurons, abnormal protein deposition and neuroinflammation are the common patholog...
α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understand...
α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular acc...
Multiple system atrophy (MSA) closely resembles Parkinson's disease clinically but with a range of a...
Alpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson’s disea...
Several neurodegenerative disorders are characterized by intracellular protein accumulations or incl...
Background: Glia are traditionally known as support cells for neurons, and their role in neurodegene...
Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Pa...
Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates,...
Abstract α-Synuclein (AS)-positive inclusions are the pathological hallmark of Parkinson’s disease (...
Abstractα-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative disorders such...
Synucleinopathies encompass several neurodegenerative diseases, which include Parkinson's disease, d...
Multiple system atrophy, characterized by atypical Parkinsonism, results from central nervous system...
A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identific...
α-Synucleinopathies comprise a group of neurodegenerative disorders that share α-synuclein (αS) accu...
Selective loss of neurons, abnormal protein deposition and neuroinflammation are the common patholog...
α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understand...
α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular acc...
Multiple system atrophy (MSA) closely resembles Parkinson's disease clinically but with a range of a...
Alpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson’s disea...
Several neurodegenerative disorders are characterized by intracellular protein accumulations or incl...
Background: Glia are traditionally known as support cells for neurons, and their role in neurodegene...
Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Pa...
Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates,...