SummaryChromosome-dependent spindle assembly requires the chromosomal recruitment and activation of Aurora B, the kinase subunit of the chromosomal passenger complex (CPC). It remains unclear how the chromosome-activated kinase spatially transmits signals to organize the micron-scale spindle. Here we reveal that the CPC must detect two structures, chromosomes and microtubules, to support spindle assembly in Xenopus egg extracts. While Aurora B is enriched on chromosomes in metaphase, we establish that a fraction of Aurora B is targeted to the metaphase spindle and phosphorylates microtubule-bound substrates. We demonstrate that chromosomally activated Aurora B must be targeted to microtubules to drive spindle assembly. Moreover, although th...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...
SummaryIn animal and plant cells, mitotic chromatin locally generates microtubules that self-organiz...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...
SummaryChromosome-dependent spindle assembly requires the chromosomal recruitment and activation of ...
SummaryChromatin-induced spindle assembly depends on regulation of microtubule-depolymerizing protei...
AbstractIn cells lacking centrosomes, such as those found in female meiosis, chromosomes must nuclea...
SummaryDuring animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromati...
Chromosome segregation during cell division requires spindle assembly around M-phase chromatin. In c...
During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2...
SummaryDuring cell division, correct positioning of chromosomes in mitotic and meiotic spindles depe...
Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here ...
<div><p>Aurora-B is the kinase subunit of the Chromosome Passenger Complex (CPC), a key regulator of...
Aurora-B is the kinase subunit of the Chromosome Passenger Complex (CPC), a key regulator of mitotic...
AbstractThe chromosomal passenger complex plays important roles in key mitotic events, including chr...
AbstractBackground: Sister kinetochores must bind microtubules in a bipolar fashion to equally segre...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...
SummaryIn animal and plant cells, mitotic chromatin locally generates microtubules that self-organiz...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...
SummaryChromosome-dependent spindle assembly requires the chromosomal recruitment and activation of ...
SummaryChromatin-induced spindle assembly depends on regulation of microtubule-depolymerizing protei...
AbstractIn cells lacking centrosomes, such as those found in female meiosis, chromosomes must nuclea...
SummaryDuring animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromati...
Chromosome segregation during cell division requires spindle assembly around M-phase chromatin. In c...
During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2...
SummaryDuring cell division, correct positioning of chromosomes in mitotic and meiotic spindles depe...
Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here ...
<div><p>Aurora-B is the kinase subunit of the Chromosome Passenger Complex (CPC), a key regulator of...
Aurora-B is the kinase subunit of the Chromosome Passenger Complex (CPC), a key regulator of mitotic...
AbstractThe chromosomal passenger complex plays important roles in key mitotic events, including chr...
AbstractBackground: Sister kinetochores must bind microtubules in a bipolar fashion to equally segre...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...
SummaryIn animal and plant cells, mitotic chromatin locally generates microtubules that self-organiz...
During cell division the genetic material on chromosomes is distributed to daughter cells by a dynam...