Influence of Inflammatory Mediators and Cytokines on Human Melanocyte Function

The fully differentiated human melanocyte functions as a necessary and integral part of the epidermis, synthesizing melanin in intracellular organelles and transferring these pigment-containing organelles to surrounding keratino-cytes. The epidermal environment contains multiple inflammatory mediators, cytokines, and growth factors that may alter constitutive melanocyte function. Constitutive melanocyte function can also be markedly altered by release of such mediators in inflammatory dermatoses. Many of the same factors can also be released by ultraviolet radiation and psoralen + ultraviolet A treatment. These inflammatory mediators and cytokines affect not only melanocyte pigment production, but also proliferation, differentiation, immunologic susceptibility and cytotoxicity, inflammatory mediator, cytokine and matrix protein production, and cell movement. The effect of inflammatory mediators and cytokines on melanocytes and the regulation of these effects are an active area of investigation. J Invest Dermatol 100:191S–195S, 199