Structural variations are common in the human genome, but their contributions to human diseases have been hard to define. Lupiáñez et al. demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene expression patterns, and developmental disorders
The organization and folding of chromatin within the nucleus can determine the outcome of gene expre...
SummaryDeciphering the impact of genetic variants on gene regulation is fundamental to understanding...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Structural variations are common in the human genome, but their contributions to human diseases have...
The potential impact of structural variants includes not only the duplication or deletion of coding ...
BACKGROUND: The number of reported examples of chromatin architecture alterations involved in the re...
SummaryMammalian genomes are organized into megabase-scale topologically associated domains (TADs). ...
A precise three-dimensional (3D) organization of chromatin is central to achieve the intricate trans...
Deoxyribonucleic acid (DNA) is also known as ‘the building block of life’. It unifies us as a specie...
Three-dimensional spatial organization of chromosomes is defined by highly self-interacting regions ...
The discovery of domains of preferential interaction or Topologically Associating Domains (TADs) has...
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demo...
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demo...
Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, inc...
Background Three-dimensional spatial organization of chromosomes is defined by highly self-interacti...
The organization and folding of chromatin within the nucleus can determine the outcome of gene expre...
SummaryDeciphering the impact of genetic variants on gene regulation is fundamental to understanding...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Structural variations are common in the human genome, but their contributions to human diseases have...
The potential impact of structural variants includes not only the duplication or deletion of coding ...
BACKGROUND: The number of reported examples of chromatin architecture alterations involved in the re...
SummaryMammalian genomes are organized into megabase-scale topologically associated domains (TADs). ...
A precise three-dimensional (3D) organization of chromatin is central to achieve the intricate trans...
Deoxyribonucleic acid (DNA) is also known as ‘the building block of life’. It unifies us as a specie...
Three-dimensional spatial organization of chromosomes is defined by highly self-interacting regions ...
The discovery of domains of preferential interaction or Topologically Associating Domains (TADs) has...
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demo...
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demo...
Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, inc...
Background Three-dimensional spatial organization of chromosomes is defined by highly self-interacti...
The organization and folding of chromatin within the nucleus can determine the outcome of gene expre...
SummaryDeciphering the impact of genetic variants on gene regulation is fundamental to understanding...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
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