A multi-centre prospective development study evaluating focal therapy using high intensity focused ultrasound for localised prostate cancer: The INDEX study

Dickinson, L.
Ahmed, H.U.
Kirkham, A.P.
Allen, C.
Freeman, A.
Barber, J.
Hindley, R.G.
Leslie, T.
Ogden, C.
Persad, R.
Winkler, M.H.
Emberton, M.

Open link

Publication date

September 2013

DOI

10.1016/j.cct.2013.06.005

Publisher

Published by Elsevier Inc.

Abstract

AbstractIntroductionFocal therapy offers the possibility of cancer control, without the side effect profile of radical therapies. Early single centre prospective development studies using high intensity focused ultrasound (HIFU) have demonstrated encouraging genitourinary functional preservation and short-term cancer control. Large multi-centre trials are required to evaluate medium-term cancer control and reproduce functional recovery. We describe the study design of an investigator-led UK multi-centre, single arm trial using HIFU to deliver focal therapy for men with localised prostate cancer.MethodsOne-hundred and forty men with histologically proven localised low or intermediate risk prostate cancer (PSA<15, Gleason ≤7, ≤T2cN0M0) will u...