Interaction of a synthetic peptide of the interferon α-2 C-terminal part with human blood leukocytes Binding to peripheral blood mononuclear cells
- Danilkovitch, A.V.
- Kharitonenkov, A.I.
- Freze, K.V.
- Shevalier, A.F.
- Kolosova, O.V.
- Bulargina, T.V.
- Kirkin, A.F.
- Gusev, M.V.
DOIAbstract
AbstractA biologically active synthetic peptide, 2438, representing the 124–138 amino acid sequence of the human interferon α-2 (IFN α-2) molecule, which is known to possess IFN-like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different Kfd values, for the ‘low’ and ‘high’ affinity binding. The interaction of the 125I-labelled peptide 2438 with the cells is not impaired by human IFN α-2 or cholera toxin
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