IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals
- Machmach, K.
- Abad-Molina, C.
- Romero-Sánchez, M.C.
- Dominguez-Molina, B.
- Moyano, M.
- Rodriguez, M.M.
- Rafii-El-Idrissi Benhnia, M.
- Jimenez-Mejias, M.E.
- Vidal, F.
- Muñoz-Fernández, M.A.
- Genebat, M.
- Viciana, P.
- González-Escribano, M.F.
- Leal, M.
- Ruiz-Mateos, E.
Publication date
March 2015
DOI Publisher
European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.Abstract
AbstractThe IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections
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