Association between Offset of the Pupil Center from the Corneal Vertex and Wavefront Aberration

AbstractPurposeTo investigate the influence of offsets of the pupil center from the corneal vertex on wavefront aberrations in the anterior cornea and the whole eye.MethodsBoth right and left eyes of 103 subjects were measured for the wavefront aberrations in the anterior cornea, along with the offset of the pupil center relative to the corneal vertex, using a Humphrey corneal topographer, and for the wavefront aberration in the whole eye using a WASCA wavefront sensor. Correlations of the pupil center offsets with the Zernike aberrations were tested.ResultsX-axis shift of the pupil center from the corneal vertex was significantly correlated to horizontal coma for both the right (r = 0.54, P<0.0001) and left eyes (r=0.48, P