The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible
- Carlier, Marie-France
- Pantaloni, Dominique
- Evans, John A.
- Lambooy, Peter K.
- Korn, Edward D.
- Webb, Martin R.
DOIAbstract
AbstractThe hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin → F-ADP-Pi-actin
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