Evaluation Of The Phototoxic Potential Of Topically Applied Agents Using Long-Wave Ultraviolet Light**From the Johnson & Johnson Research Foundation, New Brunswick, New Jersey.
- Stott, Charles W.
- Stasse, Jeanette
- Bonomo, Ronald
- Campbell, A.H.
Publication date
November 1970
DOI Publisher
The Williams & Wilkins Co. Published by Elsevier Inc.Abstract
A screening procedure for the detection of topically applied phototoxic agents is presented. Following application to the guinea pig ear, the significance of changes in ear thickness in irradiated and non-irradiated animals served as the determinant in establishing positive effects. Eight drugs reported to be phototoxic agents and hexachlorophene, which is suspected of being a photoallergen, were tested. Positive results were obtained with 8-methoxypsoralen, chlorpromazine, prochlorperazine and demethyl-chlortetracycline
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