Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis

Kestenbaum, Bryan R.
Adeney, Kathryn L.
de Boer, Ian H.
Ix, Joachim H.
Shlipak, Michael G.
Siscovick, David S.

Open link

Publication date

November 2009

DOI

10.1038/ki.2009.298

Publisher

International Society of Nephrology. Published by Elsevier Inc.

Abstract

We studied the incidence and progression of coronary artery calcification in people with early chronic kidney disease. We used a cohort of 562 adult patients with chronic kidney disease who had an estimated glomerular filtration rate of <60ml/min/1.73m2, in a community-based study of people without clinical cardiovascular disease, the Multi-Ethnic Study of Atherosclerosis. The majority had stage 3 disease. Coronary artery calcification was measured at baseline and again approximately 1.6 or 3.2 years later. The prevalence of coronary artery calcification at baseline was 66%, and its adjusted prevalence was 24% lower in African Americans as compared to Caucasians. The incidence of coronary artery calcification was 6.1% per year in women and ...