0030: Predictors of one-year mortality in newly diagnosed chronic systolic heart failure

Objectiveidentifying and measuring predictors of one-year mortality in newly diagnosed chronic systolic heart failure.Methodswe conducted a longitudinal prospective analytical bi -centric study, with one year follow-up.Results206 patients were enrolled with a mean age of 54.9±1.8 years, a sex ratio of 1.9. The prevalence of diabetes mellitus was 39.8%, hypertension 30.1%. Coronary artery disease was present in 50.5%, dilated cardiomyopathy in 30.1% and toxic cardiomyopathy in 1.9%. The mortality rate was 12.7% (11.7% in men vs 14.2% in women, p not significant) and re-admission rate was 17.6% (23,1% for men vs 6,6% in women, p=0.004). Most clinical, echographic, biological and functional parameters cited in the literature have demonstrated prognostic predictive value with different rates of sensitivity and specificity. In multivariate analysis, pulmonary vascular resistance (new highly sensitive and specific parameter, RR 47), BNP, TAPSE, dP/dt, the distance travelled in six-minutes’ walk test and serum sodium level were predictors of mortality in heart failure. The median survival by Kaplan- Meier was 24 months, with no gender difference. All parameters influencing mortality had an impact on survival. Improving the quality of life as measured by the sixminutes’ walk test and the MINNESOTA questionnaire was significantly improved in patients remained alive.Conclusionthe evaluation of drug prescriptions trends, according to new international guidelines, is quite reassuring in that the new molecules that allowed a significant reduction in morbidity and mortality in heart failure are widely prescribed in our patients