AbstractNucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA), the template for viral RNA synthesis. It remains uncertain if levels of cccDNA decline primarily through hepatocyte death, or if loss also occurs during hepatocyte mitosis. To determine if cccDNA survives mitosis, growing ducklings infected with duck hepatitis B virus (DHBV) were treated with the nucleoside analogue, Entecavir. Viremia was suppressed at least 105-fold, during a period when average liver mass increased...
Short-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early stage o...
We recently reported the development of a successful post-exposure combination antiviral and “prime-...
AbstractCovalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B ...
AbstractNucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically u...
AbstractResidual hepatitis B virus (HBV) DNA can be detected following the resolution of acute HBV i...
Residual hepatitis B virus (HBV) DNA can be detected following the resolution of acute HBV infection...
Copyright © 2005, American Society for Microbiology.Residual hepatitis B virus (HBV) DNA can be dete...
Previous mutation based studies showed that ablating synthesis of viral envelope proteins led to ele...
Hepadnaviruses replicate by reverse transcription, which takes place in the cytoplasm of the infecte...
Hepadnaviruses can cause not only acute but also chronic infections. The regulation of the copy numb...
AbstractShort-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early...
b-L-Nucleoside analogs represent a new class of potent antiviral agents with low cytotoxicity which ...
<div><p>Previous studies have demonstrated that nucleic acid polymers (NAPs) have both entry and pos...
Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the...
This study was designed to test the efficacy of antiviral treatment with entecavir (ETV) in combinat...
Short-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early stage o...
We recently reported the development of a successful post-exposure combination antiviral and “prime-...
AbstractCovalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B ...
AbstractNucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically u...
AbstractResidual hepatitis B virus (HBV) DNA can be detected following the resolution of acute HBV i...
Residual hepatitis B virus (HBV) DNA can be detected following the resolution of acute HBV infection...
Copyright © 2005, American Society for Microbiology.Residual hepatitis B virus (HBV) DNA can be dete...
Previous mutation based studies showed that ablating synthesis of viral envelope proteins led to ele...
Hepadnaviruses replicate by reverse transcription, which takes place in the cytoplasm of the infecte...
Hepadnaviruses can cause not only acute but also chronic infections. The regulation of the copy numb...
AbstractShort-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early...
b-L-Nucleoside analogs represent a new class of potent antiviral agents with low cytotoxicity which ...
<div><p>Previous studies have demonstrated that nucleic acid polymers (NAPs) have both entry and pos...
Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the...
This study was designed to test the efficacy of antiviral treatment with entecavir (ETV) in combinat...
Short-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early stage o...
We recently reported the development of a successful post-exposure combination antiviral and “prime-...
AbstractCovalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B ...