The diagnostic utility of High-Sensitivity Cardiac Troponin T in acute coronary syndrome

AbstractBackgroundCoronary artery disease (CAD), its acute form, and acute coronary syndrome (ACS) are the leading cause of death all over the world. For initial assessment of a patient with ACS, ECG, imaging techniques and serum biomarkers all contribute in confirming the diagnosis. Cardiac Troponin (cTn) I and T are the current gold standard for the detection of myocardial necrosis. However, there is also emerging evidence suggesting that with the use of sensitive or high-sensitive cTn assays, a blood sample collected 2 or 3h after presentation might be appropriate for an earlier rule in and rule out diagnosis of AMI compared with the recommended second blood draw 6–9h after admission using conventional Troponin assay.AimThe aim of this study was to examine the ability of High-Sensitivity Cardiac Troponin T for early detection of AMI in comparison with conventional Troponin assay. In addition, to study the clinical utility of kinetic changes of High-Sensitivity Cardiac Troponin T for diagnosis of ACS.MethodsThis study was conducted on sixty subjects. Fifty patients who presented to emergency department in Ain-Shams University Hospital complaining of chest pain were highly suspicious to have acute cardiac ischemia, having no or non-specific ECG changes and their Cardiac Troponin I level on admission was below the test threshold value (100ng/L). In addition, ten subjects serving as a healthy control group were also recruited. The fifty patients were subdivided into subgroup A which included 16 patients, with hs-TnT