AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7
- Abdel-Ghany, Salah E.
- Burkhead, Jason L.
- Gogolin, Kathryn A.
- Andrés-Colás, Nuria
- Bodecker, Jared R.
- Puig, Sergi
- Peñarrubia, Lola
- Pilon, Marinus
Publication date
April 2005
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractIn plant chloroplasts two superoxide dismutase (SOD) activities occur, FeSOD and Cu/ZnSOD, with reciprocal regulation in response to copper availability. This system presents a unique model to study the regulation of metal-cofactor delivery to an organelle. The Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD. The AtCCS protein was localized to chloroplasts where it may supply copper to the stromal Cu/ZnSOD. AtCCS mRNA expression levels are upregulated in response to Cu-feeding and senescence. We propose that AtCCS expression is regulated to allow the most optimal use of Cu for photosynthesis
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