The diffusing capacity in adult cystic fibrosis

AbstractThe value of adjusting the diffusing capacity for the lung volume has been demonstrated in a large number of patients with other lung diseases but has not been validated in patients with cystic fibrosis (CF). Pulmonary function test results on a cohort of 52 adult CF patients were analyzed to determine whether the diffusing capacity of carbon monoxide by single breath method (DL COSB), when adjusted for alveolar volume (VA%), correlated with the severity of pulmonary dysfunction. The DL COSB remained within the reference range except in those with severe lung impairment (61.88±15.48%). DL COSB has a significant (P