Effects of High-Dose Modified-Release Nicotinic Acid on Atherosclerosis and Vascular Function A Randomized, Placebo-Controlled, Magnetic Resonance Imaging Study
- Lee, Justin M.S.
- Robson, Matthew D.
- Yu, Ly-Mee
- Shirodaria, Cheerag C.
- Cunnington, Colin
- Kylintireas, Ilias
- Digby, Janet E.
- Bannister, Thomas
- Handa, Ashok
- Wiesmann, Frank
- Durrington, Paul N.
- Channon, Keith M.
- Neubauer, Stefan
- Choudhury, Robin P.
DOIAbstract
ObjectivesOur aim was to determine the effects of high-dose (2 g) nicotinic acid (NA) on progression of atherosclerosis and measures of vascular function.BackgroundNA raises high-density lipoprotein cholesterol (HDL-C) and reduces low-density lipoprotein cholesterol and is widely used as an adjunct to statin therapy in patients with coronary artery disease. Although changes in plasma lipoproteins suggest potential benefit, there is limited evidence of the effects of NA on disease progression when added to contemporary statin treatment.MethodsWe performed a double-blind, randomized, placebo-controlled study of 2 g daily modified-release NA added to statin therapy in 71 patients with low HDL-C (<40 mg/dl) and either: 1) type 2 diabetes with c...
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