Reeling in the Catch: Advancing Cleavable Linkers for Proteomics

In global proteomic applications that focus on the characterization of proteins that have been derivatized using bioorthogonal chemistry, a challenge persists in the release of labeled proteins from supports used for purification. In this issue, Yang and coworkers (2010) present a detailed study of the diazobenzene-cleavable linker system as an effective solution for proteomic studies