SummaryThe ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-thresh...
International audienceThe development of addictive behavior is associated with functional and struct...
Cocaine leads to a strong euphoria, which is at the origin of its recreational use. Past the acute e...
The development of addictive behavior is associated with functional and structural plasticity in the...
The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits an...
SummaryThe ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circ...
Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and drives drug-a...
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive....
Addiction is characterized by a recurrent pattern of relapse to drug seeking and drug use. This beha...
Ventral tegmental area (VTA) dopamine (DA) neurons perform diverse functions in motivation and cogni...
Addiction is a disorder of behavioral symptoms including enhanced incentive salience of drug-associa...
All addictive drugs target the mesolimbic dopamine system that originates in the ventral tegmental a...
Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine fi...
SummaryPersistent drug-seeking behavior is hypothesized to co-opt the brain's natural reward-motivat...
Potentiation of excitatory inputs onto dopamine neurons of the ventral tegmental area (VTA) induced ...
Considerable evidence suggests that psychostimulants can exert rewarding and locomotor-stimulating e...
International audienceThe development of addictive behavior is associated with functional and struct...
Cocaine leads to a strong euphoria, which is at the origin of its recreational use. Past the acute e...
The development of addictive behavior is associated with functional and structural plasticity in the...
The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits an...
SummaryThe ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circ...
Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and drives drug-a...
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive....
Addiction is characterized by a recurrent pattern of relapse to drug seeking and drug use. This beha...
Ventral tegmental area (VTA) dopamine (DA) neurons perform diverse functions in motivation and cogni...
Addiction is a disorder of behavioral symptoms including enhanced incentive salience of drug-associa...
All addictive drugs target the mesolimbic dopamine system that originates in the ventral tegmental a...
Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine fi...
SummaryPersistent drug-seeking behavior is hypothesized to co-opt the brain's natural reward-motivat...
Potentiation of excitatory inputs onto dopamine neurons of the ventral tegmental area (VTA) induced ...
Considerable evidence suggests that psychostimulants can exert rewarding and locomotor-stimulating e...
International audienceThe development of addictive behavior is associated with functional and struct...
Cocaine leads to a strong euphoria, which is at the origin of its recreational use. Past the acute e...
The development of addictive behavior is associated with functional and structural plasticity in the...