Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality
- Wu, Vin-Cent
- Huang, Tao-Min
- Lai, Chun-Fu
- Shiao, Chih-Chung
- Lin, Yu-Feng
- Chu, Tzong-Shinn
- Wu, Pei-Chen
- Chao, Chia-Ter
- Wang, Jann-Yuan
- Kao, Tze-Wah
- Young, Guang-Huar
- Tsai, Pi-Ru
- Tsai, Hung-Bin
- Wang, Chieh-Li
- Wu, Ming-Shou
- Chiang, Wen-Chih
- Tsai, I-Jung
- Hu, Fu-Chang
- Lin, Shuei-Liong
- Chen, Yung-Ming
- Tsai, Tun-Jun
- Ko, Wen-Je
- Wu, Kwan-Dun
- on behalf of the NSARF Group,
DOIAbstract
Existing chronic kidney disease (CKD) is among the most potent predictors of postoperative acute kidney injury (AKI). Here we quantified this risk in a multicenter, observational study of 9425 patients who survived to hospital discharge after major surgery. CKD was defined as a baseline estimated glomerular filtration rate <45ml/min per 1.73m2. AKI was stratified according to the maximum simplified RIFLE classification at hospitalization and unresolved AKI defined as a persistent increase in serum creatinine of more than half above the baseline or the need for dialysis at discharge. A Cox proportional hazard model showed that patients with AKI-on-CKD during hospitalization had significantly worse long-term survival over a median follow-up o...
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