AbstractThe protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1α (HIF-1α), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1α fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts ...
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of dispara...
<p><b>(A)</b> HSF1 interaction with HSP90 WT and mutants: HEK293 cells were transfected with HA-HSF1...
Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors ...
The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription ...
AbstractThe protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transc...
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that consist of two proteins- HIF-1	...
The heterodimeric hypoxia-inducible factor-1 (HIF-1) is involved in key steps of tumor progression a...
AbstractHeat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trig...
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia...
(A) Schematic of human HIF-1α (hsHIF-1α) showing the regions involved in DNA-binding and dimerisatio...
Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of g...
Heat-shock protein 90 (HSP90) is a molecular chaperone that represents one of the most important pro...
Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the h...
AbstractHeat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trig...
The heterodimeric hypoxia-inducible factor (HIF)-1 is a master transcriptional regulator of oxygen h...
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of dispara...
<p><b>(A)</b> HSF1 interaction with HSP90 WT and mutants: HEK293 cells were transfected with HA-HSF1...
Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors ...
The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription ...
AbstractThe protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transc...
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that consist of two proteins- HIF-1	...
The heterodimeric hypoxia-inducible factor-1 (HIF-1) is involved in key steps of tumor progression a...
AbstractHeat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trig...
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia...
(A) Schematic of human HIF-1α (hsHIF-1α) showing the regions involved in DNA-binding and dimerisatio...
Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of g...
Heat-shock protein 90 (HSP90) is a molecular chaperone that represents one of the most important pro...
Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the h...
AbstractHeat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trig...
The heterodimeric hypoxia-inducible factor (HIF)-1 is a master transcriptional regulator of oxygen h...
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of dispara...
<p><b>(A)</b> HSF1 interaction with HSP90 WT and mutants: HEK293 cells were transfected with HA-HSF1...
Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors ...