SummaryToll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes. PE-DTPA, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid, is a synthetic phospholipid derivative. Two major factors contribute to the ligand specificity of TLR2-TLR1 or TLR2-TLR6 heterodimers. First, the lipid channel of TLR6 is blocked by two phenylalanines. Simultaneous mutation of these phenylalanines made TLR2-TLR6 fully responsive not only to diacylated but also ...
International audienceLipopolyamines (LPAs) are cationic lipids; they interact spontaneouslywith nuc...
Recognition of microbial molecules by mammalian host receptors is essential to mount an immune respo...
Lipopolyamines (LPAs) are cationic lipids; they interact spontaneously with nucleic acids to form li...
SummaryTLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response b...
Abstract: TLR are primary triggers of the innate im-mune system by recognizing various microorganism...
Item does not contain fulltextBacterial cell walls contain lipoproteins/peptides, which are strong m...
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. ...
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. ...
one of ten human TLRs, recognizes lipoproteins that are anchored to the bacterial membrane by lipid ...
The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl resi...
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that recognize conserved structu...
Toll-like receptor 2 (TLR2) is an important pattern recognition receptor on the surface of host immu...
TLRs are key innate immune receptors that recognize conserved features of biological molecules that ...
As pattern recognition receptors of the innate immune system, Toll-like receptors (TLRs) sense micro...
Item does not contain fulltextLipoproteins activate cells of the innate immune system via heteromers...
International audienceLipopolyamines (LPAs) are cationic lipids; they interact spontaneouslywith nuc...
Recognition of microbial molecules by mammalian host receptors is essential to mount an immune respo...
Lipopolyamines (LPAs) are cationic lipids; they interact spontaneously with nucleic acids to form li...
SummaryTLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response b...
Abstract: TLR are primary triggers of the innate im-mune system by recognizing various microorganism...
Item does not contain fulltextBacterial cell walls contain lipoproteins/peptides, which are strong m...
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. ...
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. ...
one of ten human TLRs, recognizes lipoproteins that are anchored to the bacterial membrane by lipid ...
The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl resi...
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that recognize conserved structu...
Toll-like receptor 2 (TLR2) is an important pattern recognition receptor on the surface of host immu...
TLRs are key innate immune receptors that recognize conserved features of biological molecules that ...
As pattern recognition receptors of the innate immune system, Toll-like receptors (TLRs) sense micro...
Item does not contain fulltextLipoproteins activate cells of the innate immune system via heteromers...
International audienceLipopolyamines (LPAs) are cationic lipids; they interact spontaneouslywith nuc...
Recognition of microbial molecules by mammalian host receptors is essential to mount an immune respo...
Lipopolyamines (LPAs) are cationic lipids; they interact spontaneously with nucleic acids to form li...