AbstractOver the last twenty years, evidence has been provided that the plasma membrane is partitioned with microdomains, laterally mobile in the bilayer, providing the necessary microenvironment to specific membrane proteins for signalling pathways to be initiated. We discuss here the importance of such microdomains for Toll-like receptors (TLR) localization and function. First, lipid microdomains favour recruitment and clustering of the TLR machinery partners, i.e. receptors and co-receptors previously identified to be required for ligand recognition and signal transmission. Further, the presence of the so-called Cholesterol Recognition Amino-Acid Consensus (CRAC) sequences in the intracellular juxtamembrane domain of several Toll-like re...
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.Vita.Includes bibliogr...
Toll-like receptors (TLRs) play central roles in the innate immune response by recognizing conserved...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs for...
Over the last twenty years, evidence has been provided that the plasma membrane is partitioned with ...
Toll-like receptors (TLRs) are receptors of the innate immune system responsible for recognizing pat...
The spatial organization of transmembrane receptors is a critical step in signal transduction and re...
Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern r...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
Purpose of reviewReception and transmission of signals across the plasma membrane has been a functio...
The plasma membrane of immune cells is a highly organized cell structure that is key to the initiati...
SummaryThe Toll-like receptors (TLRs) of the innate immune system are unusual in that individual fam...
AbstractMembrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicat...
Toll-like receptors (TLRs) are important transmembrane proteins of the innate immune system that det...
Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to...
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.Vita.Includes bibliogr...
Toll-like receptors (TLRs) play central roles in the innate immune response by recognizing conserved...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs for...
Over the last twenty years, evidence has been provided that the plasma membrane is partitioned with ...
Toll-like receptors (TLRs) are receptors of the innate immune system responsible for recognizing pat...
The spatial organization of transmembrane receptors is a critical step in signal transduction and re...
Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern r...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of ...
Purpose of reviewReception and transmission of signals across the plasma membrane has been a functio...
The plasma membrane of immune cells is a highly organized cell structure that is key to the initiati...
SummaryThe Toll-like receptors (TLRs) of the innate immune system are unusual in that individual fam...
AbstractMembrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicat...
Toll-like receptors (TLRs) are important transmembrane proteins of the innate immune system that det...
Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to...
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.Vita.Includes bibliogr...
Toll-like receptors (TLRs) play central roles in the innate immune response by recognizing conserved...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs for...