Effects of caspase inhibition on the progression of experimental glomerulonephritis.BackgroundCaspase-3 has a central role in the execution of apoptosis. In a nephrotoxic nephritis (NTN) model, we previously demonstrated an up-regulation of caspase-3 that was associated with inappropriate renal apoptosis, inflammation, tubular atrophy, and renal scarring.MethodsWe applied a pan caspase inhibitor, Boc-Asp (OMe)-fluoro-methyl-ketone (B-D-FMK), directly to rat NTN kidney using an intrarenal cannula fed from an osmotic pump. Animals were treated either for the first 7 days (acutely) to determine the effects on renal inflammation (ED-1 staining) and apoptosis (in situ end labeling of fragmented DNA), or for 28 days commencing 15 days after NTN (...
Apoptosis and chemokine induction after renal ischemia-reperfusion.Daemen MA, de Vries B, van't Veer...
Activation of p38 mitogen-activated protein kinase (MAPK) is known to be important in cytokine produ...
Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion....
Caspase-3 and apoptosis in experimental chronic renal scarring.BackgroundCaspase-3 is a member of th...
A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glome...
Caspase activation has been implicated in the development of ischemia–reperfusion injury. Here, we i...
Caspase activation has been implicated in the development of ischemia-reperfusion injury. Here, we i...
Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases,...
The caspase family of enzymes participates in apoptotic and proinflammatory reactions in any cell. H...
Caspases are the main executioners of apoptosis as well as interleukin (IL)-1 beta and IL-18 convers...
Caspase-1–deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosi...
Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor f...
Renal cell apoptosis in chronic obstructive uropathy: The roles of caspases.BackgroundApoptosis of t...
Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).Backg...
Cyclosporine A induces apoptosis in murine tubular epithelial cells: Role of caspases.BackgroundThe ...
Apoptosis and chemokine induction after renal ischemia-reperfusion.Daemen MA, de Vries B, van't Veer...
Activation of p38 mitogen-activated protein kinase (MAPK) is known to be important in cytokine produ...
Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion....
Caspase-3 and apoptosis in experimental chronic renal scarring.BackgroundCaspase-3 is a member of th...
A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glome...
Caspase activation has been implicated in the development of ischemia–reperfusion injury. Here, we i...
Caspase activation has been implicated in the development of ischemia-reperfusion injury. Here, we i...
Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases,...
The caspase family of enzymes participates in apoptotic and proinflammatory reactions in any cell. H...
Caspases are the main executioners of apoptosis as well as interleukin (IL)-1 beta and IL-18 convers...
Caspase-1–deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosi...
Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor f...
Renal cell apoptosis in chronic obstructive uropathy: The roles of caspases.BackgroundApoptosis of t...
Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).Backg...
Cyclosporine A induces apoptosis in murine tubular epithelial cells: Role of caspases.BackgroundThe ...
Apoptosis and chemokine induction after renal ischemia-reperfusion.Daemen MA, de Vries B, van't Veer...
Activation of p38 mitogen-activated protein kinase (MAPK) is known to be important in cytokine produ...
Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion....