SummaryTight regulation of NF-κB signaling is essential for innate and adaptive immune responses, yet the molecular mechanisms responsible for its negative regulation are not completely understood. Here, we report that NLRX1, a NOD-like receptor family member, negatively regulates Toll-like receptor-mediated NF-κB activation. NLRX1 interacts with TRAF6 or IκB kinase (IKK) in an activation signal-dependent fashion. Upon LPS stimulation, NLRX1 is rapidly ubiquitinated, disassociates from TRAF6, and then binds to the IKK complex, resulting in inhibition of IKKα and IKKβ phosphorylation and NF-κB activation. Knockdown of NLRX1 in various cell types markedly enhances IKK phosphorylation and the production of NF-κB-responsive cytokines after LPS ...
During pathogen infection, innate immunity is initiated via the recognition of microbial products by...
SummaryStringent control of the NF-κB and type I interferon signaling pathways is critical to effect...
Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivo...
SummaryTight regulation of NF-κB signaling is essential for innate and adaptive immune responses, ye...
SummaryThe nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate inna...
Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of pathogen recognit...
In this issue of Immunity, Allen et al. (2011) and Xia et al. (2011) provide in vivo and biochemical...
The nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins regulate innate immu...
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR)...
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR)...
Several members of the NLR family of sensors activate innate immunity. In contrast, we found here th...
NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their ro...
NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regulate imm...
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in...
SummaryNOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regul...
During pathogen infection, innate immunity is initiated via the recognition of microbial products by...
SummaryStringent control of the NF-κB and type I interferon signaling pathways is critical to effect...
Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivo...
SummaryTight regulation of NF-κB signaling is essential for innate and adaptive immune responses, ye...
SummaryThe nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate inna...
Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of pathogen recognit...
In this issue of Immunity, Allen et al. (2011) and Xia et al. (2011) provide in vivo and biochemical...
The nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins regulate innate immu...
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR)...
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR)...
Several members of the NLR family of sensors activate innate immunity. In contrast, we found here th...
NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their ro...
NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regulate imm...
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in...
SummaryNOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regul...
During pathogen infection, innate immunity is initiated via the recognition of microbial products by...
SummaryStringent control of the NF-κB and type I interferon signaling pathways is critical to effect...
Tight regulation of inflammatory cytokine and interferon (IFN) production in innate immunity is pivo...