Effects of Compound Danshen tablets on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease

QIN, Ren-an
YAO, Xiao-xuan
HUANG, Zhu-ying

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Publication date

March 2012

DOI

10.1016/S0254-6272(12)60033-8

Publisher

The Editorial Board of Journal of Traditional Chinese Medicine. Published by Elsevier (Singapore) Pte Ltd.

Abstract

AbstractObjectiveTo observe the effects of Compound Danshen Tablets (CDST) on spatial cognition and expression of brain b-amyloid precursor protein (β-APP) in a rat model of Alzheimer's disease.MethodsThe rat model of Alzheimer's disease (AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage. Rat behavior was monitored using the Morris water maze, and the expression of β-APP in rat brain tissue was detected via immunohistochemistry.ResultsCDST significantly improved spatial cognition and decreased β-APP expression in the cortex and hippocampus (P<0.05, P<0.01).ConclusionsCDST can significantly improve spatial cognition in a rat model of AD. This observation is possibly related to a reduction in β...

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Effects of Compound Danshen tablets on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease

Abstract

Extracted data

Effects of Compound Danshen tablets on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease

Abstract

Extracted data

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