In this issue of Cancer Cell, Schwartz and colleagues and Costa and colleagues demonstrate that inhibition of PI3Kα or PI3Kβ in cancer cells with hyperactivated PI3Kα or PI3Kβ, respectively, activates the other isoform, leading to a “rebound” of the PI3K activity through different compensation mechanisms
Frequent subversion of the PI3K (phosphoinositide 3-kinase) pathway during neoplastic transformation...
In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 k...
There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-k...
Small molecule inhibitors of PI3K for oncology mainly target the class I PI3Ks, comprising the p110 ...
Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into thre...
Phosphatidylinositol-3-kinase (PI3K) enzymes, producing signaling phosphoinositides at plasma and in...
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate multiple biological funct...
Phosphoinositide 3-kinases (PI3Ks) are signalling enzymes that play important roles in various cellu...
Phosphoinositide 3-kinases (PI3Ks) are considered promising drug targets in oncology. In this issue ...
SummaryIn PTEN-mutated tumors, we show that PI3Kα activity is suppressed and PI3K signaling is drive...
Abstract. Background: Eight human catalytic phosphoino-sitide 3-kinase (PI3K) isoforms exist which a...
Genetic activation of the class I PI3K pathway is very common in cancer. This mostly results from on...
Phosphatidylinositol 3-kinases (PI3Ks) are key molecules in the signal transduction pathways initiat...
Members of the phosphoinositide 3-kinase (PI3K) family collectively control multiple cellular respon...
Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into thre...
Frequent subversion of the PI3K (phosphoinositide 3-kinase) pathway during neoplastic transformation...
In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 k...
There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-k...
Small molecule inhibitors of PI3K for oncology mainly target the class I PI3Ks, comprising the p110 ...
Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into thre...
Phosphatidylinositol-3-kinase (PI3K) enzymes, producing signaling phosphoinositides at plasma and in...
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate multiple biological funct...
Phosphoinositide 3-kinases (PI3Ks) are signalling enzymes that play important roles in various cellu...
Phosphoinositide 3-kinases (PI3Ks) are considered promising drug targets in oncology. In this issue ...
SummaryIn PTEN-mutated tumors, we show that PI3Kα activity is suppressed and PI3K signaling is drive...
Abstract. Background: Eight human catalytic phosphoino-sitide 3-kinase (PI3K) isoforms exist which a...
Genetic activation of the class I PI3K pathway is very common in cancer. This mostly results from on...
Phosphatidylinositol 3-kinases (PI3Ks) are key molecules in the signal transduction pathways initiat...
Members of the phosphoinositide 3-kinase (PI3K) family collectively control multiple cellular respon...
Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into thre...
Frequent subversion of the PI3K (phosphoinositide 3-kinase) pathway during neoplastic transformation...
In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 k...
There is extensive evidence from the molecular and genomic analysis of human cancers that the PI 3-k...
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