Self-reactive B cells are eliminated during development by antibody-affinity selection and receptor-editing mechanisms. Work by Isnardi et al. (2008) in this issue of Immunity suggests that removal of autoreactivity from the immature B cell pool also requires innate immunity pathways
AbstractSelf-reactive B cells Tg for both a bcl-xL death inhibitory gene and an Ig receptor recogniz...
How B cells discriminate antigen-receptor-mediated signals in development and navigate critical chec...
Studies performed in animal models and in humans indicate that the innate arm of the immune system p...
The development of an adaptive immune system based on the random generation of antigen receptors req...
AbstractB lymphocyte development is a highly ordered process that involves immunoglobulin gene rearr...
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segme...
B lymphocyte receptors are generated randomly during the bone marrow developmental phase of B cells....
Work from multiple groups continues to provide additional evidence for the powerful and highly diver...
In humans, up to 75% of newly generated B cells and about 30% of mature B cells show some degree of ...
Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the productio...
Immature B cells that encounter self-antigen are eliminated from the immune repertoire by a process ...
Self-reactive B cells are tolerized at various stages of B-cell development and differentiation, inc...
In normal B cell development, a large percentage of newly formed cells bear receptors with high leve...
International audienceB cell tolerance or autoimmunity is determined by selective events. Negative s...
AbstractSeveral powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete ...
AbstractSelf-reactive B cells Tg for both a bcl-xL death inhibitory gene and an Ig receptor recogniz...
How B cells discriminate antigen-receptor-mediated signals in development and navigate critical chec...
Studies performed in animal models and in humans indicate that the innate arm of the immune system p...
The development of an adaptive immune system based on the random generation of antigen receptors req...
AbstractB lymphocyte development is a highly ordered process that involves immunoglobulin gene rearr...
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segme...
B lymphocyte receptors are generated randomly during the bone marrow developmental phase of B cells....
Work from multiple groups continues to provide additional evidence for the powerful and highly diver...
In humans, up to 75% of newly generated B cells and about 30% of mature B cells show some degree of ...
Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the productio...
Immature B cells that encounter self-antigen are eliminated from the immune repertoire by a process ...
Self-reactive B cells are tolerized at various stages of B-cell development and differentiation, inc...
In normal B cell development, a large percentage of newly formed cells bear receptors with high leve...
International audienceB cell tolerance or autoimmunity is determined by selective events. Negative s...
AbstractSeveral powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete ...
AbstractSelf-reactive B cells Tg for both a bcl-xL death inhibitory gene and an Ig receptor recogniz...
How B cells discriminate antigen-receptor-mediated signals in development and navigate critical chec...
Studies performed in animal models and in humans indicate that the innate arm of the immune system p...
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