SummaryIn central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) evokes a complex synaptic response consisting of IP3 receptor-dependent Ca2+ release from internal Ca2+ stores and a slow depolarizing potential involving TRPC3 channels. It is largely unclear how mGluR1 is linked to its downstream effectors. Here, we explored the role of stromal interaction molecule 1 (STIM1) in regulating neuronal Ca2+ signaling and mGluR1-dependent synaptic transmission. By analyzing mouse cerebellar Purkinje neurons, we demonstrate that STIM1 is an essential regulator of the Ca2+ level in neuronal endoplasmic reticulum Ca2+ stores. Both mGluR1-dependent synaptic potentials and IP3 receptor-dependent Ca2+ signals are strongl...
STIM2 is an integral membrane protein of the endoplasmic reticulum (ER) that regulates the activity ...
SummaryIn the mammalian central nervous system, slow synaptic excitation involves the activation of ...
International audienceIn cerebellar cortex, mGlu4 receptors located on parallel fibers play an essen...
SummaryIn central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) ev...
학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의과학과, 2018. 2. 김상정.Proper regulation of cytosolic calcium is important ...
Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces ...
Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces ...
STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticul...
Group 1 metabotropic glutamate receptors (mGlu1/5) are critical to synapse formation and participate...
During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapse...
Neuronal calcium (Ca2+) influx has long been ascribed mainly to voltage-gated Ca2+ channels and glut...
The cerebellum is a brain structure involved in coordination, control, and learning of movements, as...
Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM pro...
International audienceType 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in differe...
Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STI...
STIM2 is an integral membrane protein of the endoplasmic reticulum (ER) that regulates the activity ...
SummaryIn the mammalian central nervous system, slow synaptic excitation involves the activation of ...
International audienceIn cerebellar cortex, mGlu4 receptors located on parallel fibers play an essen...
SummaryIn central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) ev...
학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의과학과, 2018. 2. 김상정.Proper regulation of cytosolic calcium is important ...
Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces ...
Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces ...
STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticul...
Group 1 metabotropic glutamate receptors (mGlu1/5) are critical to synapse formation and participate...
During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapse...
Neuronal calcium (Ca2+) influx has long been ascribed mainly to voltage-gated Ca2+ channels and glut...
The cerebellum is a brain structure involved in coordination, control, and learning of movements, as...
Store-operated Ca2+-entry (SOCE) regulates basal and receptor-triggered Ca2+ signaling with STIM pro...
International audienceType 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in differe...
Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STI...
STIM2 is an integral membrane protein of the endoplasmic reticulum (ER) that regulates the activity ...
SummaryIn the mammalian central nervous system, slow synaptic excitation involves the activation of ...
International audienceIn cerebellar cortex, mGlu4 receptors located on parallel fibers play an essen...