SummaryEsophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression of interleukin-1β phenocopies human pathology with evolution of esophagitis, Barrett-like metaplasia and EAC. Histopathology and gene signatures closely resembled human BE, with upregulation of TFF2, Bmp4, Cdx2, Notch1, and IL-6. The development of BE and EAC was accelerated by exposure to bile acids and/or nitrosamines, and inhibited by IL-6 deficiency. Lgr5+ gastric cardia stem cells present in BE were able to lineage trace the early BE lesion. Our data suggest that BE and EAC arise from gastric progenitors due to a tumor-promoting IL-1β-IL...
Abstract Background Investigation of the expression of an intestinal stem cell marker in esophageal ...
Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progr...
Oesophageal exposure to duodenogastroesophageal refluxate is implicated in the development of Barret...
Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metapla...
SummaryEsophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar ...
Bile acid reflux is known to be associated with the development of Barrett’s esophagus and esophagea...
Bile acid reflux is known to be associated with the development of Barrett's esophagus and esophagea...
Barrett's esophagus (BE) is associated with the development of esophageal adenocarcinoma (EAC). Bile...
SummaryBarrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinom...
© 2020 AGA Institute Background & Aims: Studies are needed to determine the mechanism by which Barre...
Barrett’s esophagus (BE) is a pre-malignant state that can proceed to the cancerous condition known ...
In recent years, gastro-oesophageal cancers have increased in incidence in the western world with no...
The molecular processes that predispose the development of Barrett’s esophagus (BE) towards esophage...
Objective: The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors contributing ...
Esophageal cancer is one of the deadliest cancers in the U.S and worldwide. Esophageal cancer is cha...
Abstract Background Investigation of the expression of an intestinal stem cell marker in esophageal ...
Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progr...
Oesophageal exposure to duodenogastroesophageal refluxate is implicated in the development of Barret...
Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metapla...
SummaryEsophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar ...
Bile acid reflux is known to be associated with the development of Barrett’s esophagus and esophagea...
Bile acid reflux is known to be associated with the development of Barrett's esophagus and esophagea...
Barrett's esophagus (BE) is associated with the development of esophageal adenocarcinoma (EAC). Bile...
SummaryBarrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinom...
© 2020 AGA Institute Background & Aims: Studies are needed to determine the mechanism by which Barre...
Barrett’s esophagus (BE) is a pre-malignant state that can proceed to the cancerous condition known ...
In recent years, gastro-oesophageal cancers have increased in incidence in the western world with no...
The molecular processes that predispose the development of Barrett’s esophagus (BE) towards esophage...
Objective: The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors contributing ...
Esophageal cancer is one of the deadliest cancers in the U.S and worldwide. Esophageal cancer is cha...
Abstract Background Investigation of the expression of an intestinal stem cell marker in esophageal ...
Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progr...
Oesophageal exposure to duodenogastroesophageal refluxate is implicated in the development of Barret...