The conserved molecular machinery in DNA mismatch repair enzyme structures
- Groothuizen, Flora S.
- Sixma, Titia K.
Publication date
February 2016
DOI Publisher
The Authors. Published by Elsevier B.V.Abstract
AbstractThe machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems
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