AbstractThe mechanistic target of rapamycin (mTOR) is a critical kinase in the regulation of gene translation and has been suggested as a potential target for radiosensitization. The goal of this study was to compare the radiosensitizing activities of the allosteric mTOR inhibitor rapamycin with that of the competitive mTOR inhibitor PP242. On the basis of immunoblot analyses, whereas rapamycin only partially inhibited mTOR complex 1 (mTORC1) activity and had no effect on mTOR complex 2 (mTORC2), PP242 inhibited the activity of both mTOR-containing complexes. Irradiation alone had no effect on mTORC1 or mTORC2 activity. Clonogenic survival was used to define the effects of the mTOR inhibitors on in vitro radiosensitivity. In the two tumor c...
Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local c...
Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic ...
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, gr...
AbstractThe mechanistic target of rapamycin (mTOR) is a critical kinase in the regulation of gene tr...
Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local c...
Purpose: Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity an...
Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Ak...
<div><p>Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Be...
INTRODUCTION: Radiation activates the PI3K/Akt pathway and inhibition of PI3K/Akt sensitizes tumor v...
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and pro...
Radioligand therapy (RLT) represents an effective strategy to treat malignancy by cancer-selective d...
FBXW7 acts as a tumor suppressor in numerous types of human cancers through ubiquitination of differ...
The present study was aimed to investigate whether combination of molecular targeting therapy, a dua...
The mammalian target of rapamycin (mTOR) was originally identified in yeast as the protein responsib...
The mammalian target of rapamycin (mTOR) functions to integrate nutrient and energy availability wit...
Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local c...
Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic ...
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, gr...
AbstractThe mechanistic target of rapamycin (mTOR) is a critical kinase in the regulation of gene tr...
Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local c...
Purpose: Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity an...
Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Ak...
<div><p>Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Be...
INTRODUCTION: Radiation activates the PI3K/Akt pathway and inhibition of PI3K/Akt sensitizes tumor v...
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and pro...
Radioligand therapy (RLT) represents an effective strategy to treat malignancy by cancer-selective d...
FBXW7 acts as a tumor suppressor in numerous types of human cancers through ubiquitination of differ...
The present study was aimed to investigate whether combination of molecular targeting therapy, a dua...
The mammalian target of rapamycin (mTOR) was originally identified in yeast as the protein responsib...
The mammalian target of rapamycin (mTOR) functions to integrate nutrient and energy availability wit...
Radiation therapy for invasive bladder cancer allows for organ preservation but toxicity and local c...
Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic ...
mTOR (mechanistic target of rapamycin) functions as the central regulator for cell proliferation, gr...