Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis
The acquisition of a motile and invasive phenotype is an important step in the development of tumors...
International audienceMetastasis is the main cause of human cancer deaths, and cell motility is one ...
Recurrence and metastasis are commonly associated with poor prognosis of hepatocellular carcinoma (H...
Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type movement is ch...
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to va...
Abstract Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton ...
Throughout the last few years cancer research has focused on studying the origin of secondary tumors...
SummaryBackgroundTumor cells can move in a three-dimensional (3D) environment in either mesenchymal-...
Metastasizing tumor cells must transmigrate the dense extracellular matrix that surrounds most organ...
Metastasis, initially driven by cells migrating and invading through the local environment, leads to...
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamides...
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamides...
Small GTPases of the Ras, Rho and Ral families play important roles in tumour biology. Genetic alter...
A major factor controlling the metastatic nature of cancer cells is their motility. Alterations in t...
Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis ...
The acquisition of a motile and invasive phenotype is an important step in the development of tumors...
International audienceMetastasis is the main cause of human cancer deaths, and cell motility is one ...
Recurrence and metastasis are commonly associated with poor prognosis of hepatocellular carcinoma (H...
Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type movement is ch...
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to va...
Abstract Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton ...
Throughout the last few years cancer research has focused on studying the origin of secondary tumors...
SummaryBackgroundTumor cells can move in a three-dimensional (3D) environment in either mesenchymal-...
Metastasizing tumor cells must transmigrate the dense extracellular matrix that surrounds most organ...
Metastasis, initially driven by cells migrating and invading through the local environment, leads to...
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamides...
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamides...
Small GTPases of the Ras, Rho and Ral families play important roles in tumour biology. Genetic alter...
A major factor controlling the metastatic nature of cancer cells is their motility. Alterations in t...
Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis ...
The acquisition of a motile and invasive phenotype is an important step in the development of tumors...
International audienceMetastasis is the main cause of human cancer deaths, and cell motility is one ...
Recurrence and metastasis are commonly associated with poor prognosis of hepatocellular carcinoma (H...
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