SummaryNodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided Nodal signaling in the epithalamic region of the zebrafish forebrain. Epithalamic Nodal signaling subsequently determines the laterality of neuroanatomical asymmetries. We show that overactivation of Wnt/Axin1/β-catenin signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of LPM Nodal signaling. This is consistent with a model whereby epithalamic Nodal signaling is normally bilaterally repressed, with Nodal signaling from the LPM unilaterally alleviating repression. We suggest that Wnt signaling regulates the establishment of the bilateral repression. We identify a second role for the...
AbstractTransient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailb...
AbstractThe establishment of the vertebrate body plan involves patterning of the ectoderm, mesoderm,...
SummaryBackgroundAlthough left-right asymmetries are common features of nervous systems, their devel...
Nodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided Nodal sig...
SummaryNodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided No...
AbstractAnimals show behavioral asymmetries that are mediated by differences between the left and ri...
SummaryThe vertebrate brain is anatomically and functionally asymmetric; however, the molecular mech...
Neuroanatomical and functional asymmetries are a widespread, probably universal, feature of the vert...
BackgroundAlthough left-right asymmetries are common features of nervous systems, their developmenta...
Background: Although left-right asymmetries are common features of nervous systems, their developmen...
Precise temporal coordination of signaling processes is pivotal for cellular differentiation during ...
AbstractThe node triggers formation of the left–right axis in mouse embryos by establishing local as...
In vertebrates, left-right (LR) axis specification is determined by a ciliated structure in the post...
Although zebrafish with situs inversus show complete reversal of normal visceral and cerebral asymme...
In vertebrates, left-right (LR) axis specification is determined by a ciliated structure in the post...
AbstractTransient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailb...
AbstractThe establishment of the vertebrate body plan involves patterning of the ectoderm, mesoderm,...
SummaryBackgroundAlthough left-right asymmetries are common features of nervous systems, their devel...
Nodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided Nodal sig...
SummaryNodal activity in the left lateral plate mesoderm (LPM) is required to activate left-sided No...
AbstractAnimals show behavioral asymmetries that are mediated by differences between the left and ri...
SummaryThe vertebrate brain is anatomically and functionally asymmetric; however, the molecular mech...
Neuroanatomical and functional asymmetries are a widespread, probably universal, feature of the vert...
BackgroundAlthough left-right asymmetries are common features of nervous systems, their developmenta...
Background: Although left-right asymmetries are common features of nervous systems, their developmen...
Precise temporal coordination of signaling processes is pivotal for cellular differentiation during ...
AbstractThe node triggers formation of the left–right axis in mouse embryos by establishing local as...
In vertebrates, left-right (LR) axis specification is determined by a ciliated structure in the post...
Although zebrafish with situs inversus show complete reversal of normal visceral and cerebral asymme...
In vertebrates, left-right (LR) axis specification is determined by a ciliated structure in the post...
AbstractTransient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailb...
AbstractThe establishment of the vertebrate body plan involves patterning of the ectoderm, mesoderm,...
SummaryBackgroundAlthough left-right asymmetries are common features of nervous systems, their devel...