AbstractThe voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form the cardiac IKs delayed rectifier potassium current and mutations in both genes can lead to the long QT syndrome. KCNQ1 can form functional homotetrameric channels, however with drastically different biophysical properties compared to heteromeric KCNQ1/KCNE1 channels. We analyzed gating and conductance of these channels expressed in Xenopus oocytes using the two-electrode voltage-clamp and the patch-clamp technique and high extracellular potassium (K) and rubidium (Rb) solutions. Inward tail currents of homomeric KCNQ1 channels are increased about threefold upon substitution of 100mM potassium with 100mM rubidium despite a smaller rubidium perm...
KCNQ1 α-subunits assemble with KCNE1 forming the slow cardiac potassium channel IKs. KCNE1 alters cu...
AbstractKv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in...
AbstractThe slow delayed rectifier (IKs) channel is composed of the KCNQ1 channel and KCNE1 auxiliar...
AbstractThe voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form th...
The voltage-gated potassium channel protein KvLQT1 (Wang et al., 1996, Nature Genet. 12:17-23) is be...
AbstractThe voltage-gated potassium channel protein KvLQT1 (Wang et al., 1996. Nature Genet. 12:17–2...
IKs channels are voltage dependent and K+ selective. They influence cardiac action potential duratio...
The slow potassium current, IKs, abbreviates the cardiac action potential by repolarizing the membra...
AbstractKCNQ1–5 (Kv7.1–7.5) subunits assemble to form a variety of functional K+ channels in the ner...
Voltage-gated potassium (Kv) channels regulate membrane excitability and are therefore critical dete...
AbstractKv7.1 (KCNQ1) channels are regulators of several physiological processes including vasodilat...
The IKs potassium channel, critical to control of heart electrical activity, requires assembly of po...
Potassium channels are transmembrane proteins that facilitate the passive and selective flux of K+ i...
Kv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in mammali...
Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardia...
KCNQ1 α-subunits assemble with KCNE1 forming the slow cardiac potassium channel IKs. KCNE1 alters cu...
AbstractKv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in...
AbstractThe slow delayed rectifier (IKs) channel is composed of the KCNQ1 channel and KCNE1 auxiliar...
AbstractThe voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form th...
The voltage-gated potassium channel protein KvLQT1 (Wang et al., 1996, Nature Genet. 12:17-23) is be...
AbstractThe voltage-gated potassium channel protein KvLQT1 (Wang et al., 1996. Nature Genet. 12:17–2...
IKs channels are voltage dependent and K+ selective. They influence cardiac action potential duratio...
The slow potassium current, IKs, abbreviates the cardiac action potential by repolarizing the membra...
AbstractKCNQ1–5 (Kv7.1–7.5) subunits assemble to form a variety of functional K+ channels in the ner...
Voltage-gated potassium (Kv) channels regulate membrane excitability and are therefore critical dete...
AbstractKv7.1 (KCNQ1) channels are regulators of several physiological processes including vasodilat...
The IKs potassium channel, critical to control of heart electrical activity, requires assembly of po...
Potassium channels are transmembrane proteins that facilitate the passive and selective flux of K+ i...
Kv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in mammali...
Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardia...
KCNQ1 α-subunits assemble with KCNE1 forming the slow cardiac potassium channel IKs. KCNE1 alters cu...
AbstractKv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in...
AbstractThe slow delayed rectifier (IKs) channel is composed of the KCNQ1 channel and KCNE1 auxiliar...