Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells

Sato, Sei-ichi
Inoue, Hiroki
Kogure, Takeshi
Tagaya, Mitsuo
Tani, Katsuko

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Publication date

November 2010

DOI

10.1016/j.febslet.2010.09.047

Publisher

Federation of European Biochemical Societies. Published by Elsevier B.V.

Abstract

AbstractMammals have three members of the intracellular phospholipase A1 protein family (phosphatidic acid preferring-phospholipase A1, p125, and KIAA0725p). In this study, we showed that KIAA0725p is localized in the Golgi, and is rapidly cycled between the Golgi and cytosol. Catalytic activity is important for targeting of KIAA0725p to Golgi membranes. RNA interference experiments suggested that KIAA0725p contributes to efficient membrane trafficking from the Golgi apparatus to the plasma membrane, but is not involved in brefeldin A-induced Golgi-to-endoplasmic reticulum retrograde transport.Structured summaryMINT-8019765: KIAA0725 (uniprotkb:O94830) and Beta-COP (uniprotkb:P53618) colocalize (MI:0403) by fluorescence microscopy (MI:0416)...

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Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells

Abstract

Extracted data

Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells

Abstract

Extracted data

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