SummaryThe establishment of a multicellular body plan requires coordinating changes in cell adhesion and the cytoskeleton to ensure proper cell shape and position within a tissue. Cell adhesion to the extracellular matrix (ECM) via integrins plays diverse, essential roles during animal embryogenesis and therefore must be precisely regulated [1]. Talin, a FERM-domain containing protein, forms a direct link between integrin adhesion receptors and the actin cytoskeleton and is an important regulator of integrin function [2]. Similar to other FERM proteins, talin makes an intramolecular interaction that could autoinhibit its activity [3–6]. However, the functional consequence of such an interaction has not been previously explored in vivo. Here...
Cell migration, growth and differentiation all require the assembly and disassembly of cellular junc...
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellula...
Tight, dynamic control of the affinity of integrin adhesion receptors for their extracellular ligand...
The establishment of a multicellular body plan requires coordinating changes in cell adhesion and th...
The establishment of a multi-cellular body plan requires coordinating changes in cell adhesion and t...
SummaryThe establishment of a multicellular body plan requires coordinating changes in cell adhesion...
<div><p>Talin serves an essential function during integrin-mediated adhesion in linking integrins to...
The morphogenesis and maintenance of three-dimensional tissue architecture requires intricate, coord...
Attachment of cells to the Extracellular Matrix (ECM) via integrins is essential for animal developm...
We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mut...
During the morphogenesis of multicellular organisms, cells undergo rearrangements and morphological ...
Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and enabling cell...
Morphogenesis is the process by which cells rearrange to form complex three dimensional structures. ...
Cell-extra cellular matrix (ECM) adhesion through the integrin family of receptors is required for m...
<p>(<b>a–c</b>) Maternal-zygotic talin null embryos (shown in a) rescued with either full-length WT ...
Cell migration, growth and differentiation all require the assembly and disassembly of cellular junc...
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellula...
Tight, dynamic control of the affinity of integrin adhesion receptors for their extracellular ligand...
The establishment of a multicellular body plan requires coordinating changes in cell adhesion and th...
The establishment of a multi-cellular body plan requires coordinating changes in cell adhesion and t...
SummaryThe establishment of a multicellular body plan requires coordinating changes in cell adhesion...
<div><p>Talin serves an essential function during integrin-mediated adhesion in linking integrins to...
The morphogenesis and maintenance of three-dimensional tissue architecture requires intricate, coord...
Attachment of cells to the Extracellular Matrix (ECM) via integrins is essential for animal developm...
We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mut...
During the morphogenesis of multicellular organisms, cells undergo rearrangements and morphological ...
Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and enabling cell...
Morphogenesis is the process by which cells rearrange to form complex three dimensional structures. ...
Cell-extra cellular matrix (ECM) adhesion through the integrin family of receptors is required for m...
<p>(<b>a–c</b>) Maternal-zygotic talin null embryos (shown in a) rescued with either full-length WT ...
Cell migration, growth and differentiation all require the assembly and disassembly of cellular junc...
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellula...
Tight, dynamic control of the affinity of integrin adhesion receptors for their extracellular ligand...