Dynamic subcellular localization of aquaporin-7 in white adipocytes
- Miyauchi, Takayuki
- Yamamoto, Hiroyuki
- Abe, Yoichiro
- Yoshida, Go J.
- Rojek, Aleksandra
- Sohara, Eisei
- Uchida, Shinichi
- Nielsen, Søren
- Yasui, Masato
Publication date
February 2015
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractAquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes
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